Expanding the femtosecond crystallography toolkit: Fig. 1.
نویسندگان
چکیده
منابع مشابه
Expanding the femtosecond crystallography toolkit.
The “21 century of biology” is built on advances in protein structure determination developed over the last five decades. Exponential growth in the number of determined protein structures has largely been driven by new technologies in protein X-ray crystallography, including synchrotron X-ray sources, X-ray detectors, computational tools, and methods of handling protein crystals. In consequence...
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X-ray free-electron lasers produce brief flashes of X-rays that are of about a billion times higher peak brightness than achievable from storage ring sources. Such a tremendous jump in X-ray source capabilities, that came in 2009 when the Linac Coherent Light Source begun operations, was unprecedented in the history of X-ray science. Protein structure determination through the method of macromo...
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Institute for Molecular Bioscience, University of Queensland, Queensland Bioscience Precinct, Brisbane, QLD 4072, Australia, Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, United Kingdom, and Photon Science, SLAC and Structural Biology, School of Medicine, Stanford University, 2575 Sand Hi...
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Protein crystallography using synchrotron radiation sources has had a tremendous impact on biology, having yielded the structures of thousands of proteins and given detailed insight into their mechanisms. However, the technique is limited by the requirement for macroscopic crystals, which can be difficult to obtain, as well as by the often severe radiation damage caused in diffraction experimen...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2014
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1419830111